Sentence examples for been implicated in reduced from inspiring English sources
This is of particular importance since expression of MDR-1 and its encoding protein P-gp have been implicated in reduced drug up-take, thereby mediating resistance to chemotherapy [ 36, 37].
We observed deterioration of trabecular architecture, decreased bone mass, and decreased cortical thickness, all of which have been implicated in reduced bone strength and increased fracture incidence in humans (Barth et al. 1992; Wachter et al. 2002).
The p53Ser220 mutation has been implicated in reduced efficacy and drug resistance in the context of osteosarcomas and breast tumors treated with doxorubicin-based protocols.
Interestingly, loss of Cx26 expression has also been implicated in reduced survival in primary gastric and colorectal carcinomas, suggesting an organ specific biological significance of Cx26 [ 34, 35].
Muscle-specific overexpression of PGC1α leads to increased endurance performance (4), whereas decreased expression has been implicated in reduced exercise tolerance, chronic inflammation, and mitochondrial myopathy (10, 20).
Alterations in collagen and elastin deposition in aged lung tissue have previously been implicated in reduced lung compliance and senescence [ 21, 22].
Dietary substances such as vitamin B, caffeine, and alcohol also have been implicated in reducing the risk of Alzheimer disease.
Soy isoflavones have been implicated in reducing the overall incidence of breast and prostate cancers in Asian countries.
Thus far, AnxA1 has been implicated in reducing granulocyte-tissue infiltration by blocking neutrophil-endothelial interactions and accelerating neutrophil apoptosis.
Orally administered curcuminoids have been implicated in reducing Aβ plaque burden and the amount of soluble Aβ in Alzheimer transgenic mice [ 20].
38 More of our tenofovir-treated cohort took oral corticosteroids, were chronic cigarette smokers, and had truncal obesity or wasting syndrome, all of which have been implicated in reducing bone mineral density.
