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CSCs have been implicated in recurrence and treatment resistance in many human cancers, including brain.
CSCs have been implicated in recurrence and treatment resistance in many human cancers including brain tumors.
Here, we demonstrate that scL crosses the BBB and efficiently targets GBM, as well as cancer stem cells (CSCs), which have been implicated in recurrence and treatment resistance in many human cancers.
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Mesenchymal gene expression in tumors has been implicated in cancer recurrence, metastasis, and poor prognosis of patients.
Thus, CSCs have been implicated in tumour recurrence and metastasis (Visvader and Lindeman 2008; Patrawala et al. 2006, 2007).
Field cancerization, as described by Slaughter et al. and expanded upon by others, is the development of genetic or epigenetic damage in normal-appearing mucosa consequent to the exposure of an entire epithelial field to carcinogens.[ 3] Field effects have been implicated in the recurrence of tumors and also in the development of second primary tumors.
Attention bias modification could be developed to target the HPA axis, which has been implicated in the increased recurrence risk of depression in people with diabetes.
Glioma-initiating cells (GICs) are stem-like cells that have been implicated in glioblastoma progression and recurrence; however, the distinct properties of GICs and non-GICs within GBM tumors are largely uncharacterized.
However, aberrant expression of CD44v has been implicated in the initiation, progression and recurrence of various human cancers [ 16- 18].
Several hypotheses, including alterations in tumor microenvironment and tumor biological factors, have been implicated in resistance to therapy and tumor recurrence.
TP53 is a tumour suppressor gene, with a well-known function in DNA repair and apoptosis (Hu et al, 2003) and has been implicated in both hepatocarcinogenesis and HCC tumour recurrence.
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