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IL-6 has further been implicated in protective signaling against ischemic injury in the heart [13].
Superoxide dismutase has been implicated in protective effects against myocardial ischemic injury.
NF-κB has been implicated in protective or degenerative pathways, dependent on the stimulus concentration [ 8] or its nature [ 9].
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These data may have an important implication in the possibility of designing effective vaccine against SARS-CoV infection, specifically in defining T-cell populations that are implicated in protective immunity.
Interestingly, Dong et al. described that the superoxide dismutase has one immunodominant epitope for cytotoxic T lymphocytes, which are implicated in protective immunity against tuberculosis [ 32].
Significant over-representation was demonstrated by functional classes that are implicated in protective reactions to acute conditions (i.e., response to stress and oxidative stress, defense and humoral immune response, receptors and regulators of transcription, Table 4).
Although EPO that is produced in an autocrine paracrine manner has been implicated in tissue protective effects in the brain, spinal cord, retina, and heart, similar protective roles in severe illnesses have not been directly evaluated.
ESAT-6 is a secreted protein of Mtb, which is absent in BCG but has been implicated in inducing protective immunity against Mtb.
Neutrophils have been implicated in both protective and pathological responses following influenza virus infections.
Induced regulatory T cells (Treg) have been implicated in the protective mechanism of DNA vaccination against other organ-specific autoimmune diseases such as murine Experimental Autoimmune Uveitis [18].
Given that neutrophils have been implicated in both protective and pathological responses following influenza virus infections, we investigated the role of neutrophils in vivo following infection with virus strains known to differ in virulence in mice.
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