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Recently, PGE2 has been implicated in promotion of EMT in vitro[ 8].
26 Recently, EP4 has been implicated in promotion of the SLC phenotype in breast cancer cells.
Despite its role in differentiation, NURR1 has been implicated in promotion of cancer cell proliferation.
IL-6 has further been implicated in promotion of tumour growth, invasion and metastasis, and the development of drug resistance (Kato et al, 1998; Esper and Harb, 2005).
Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype.
Both cyclin E and c-Myc contribute to the transition of cells from G1 to S phase (Wang et al, 2008; Malumbres and Barbacid, 2009) and have recently been implicated in promotion of caspase-dependent apoptosis subsequent to S-phase arrest induced by DNA damage or inhibition of DNA synthesis in tumour cells (Mazumder et al, 2000; Leonce et al, 2001; Lu et al, 2009; Sankar et al, 2009).
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Intensive exercise has been implicated in the promotion of free radical generation in active skeletal muscle resulting in the formation of oxidized lipids [42].
It has been implicated in tumor promotion and in the regulation of 3-phosphoinositide-dependent kinase-1 (PDK1).
As TRPC1 has been implicated in the promotion of mammalian cardiac hypertrophy [58] it may be implicated in temperature-induced cardiac hypertrophy in fish [33].
In addition, several of our invasion-specific signature genes are chemokines including CXCL1, CXCL2, and IL-8 which have been implicated in the promotion of tumor-associated angiogenesis, a critical feature of invasive tumors [57].
IL-6 has been implicated in the promotion of inflammation, cell proliferation and differentiation [ 39].
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been implicated in plaque
been recorded in promotion
been implicated in neuroinflammation
been implicated in acne
been implicated in plant
been implicated in arthritis
been implicated in atherogenesis
been implicated in insulin
been implicated in cancer
been implicated in cholesterol
been implicated in atherosclerosis
been implicated in fraud
been implicated in skin
been implicated in diabetes
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