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G protein-coupled receptors (GPCRs) and their ligands have been implicated in progression and metastasis of several cancers.
Phopholipase D (PLD) has been implicated in progression of colorectal carcinoma However, an understanding of the targets and regulation of this important pathway remains incomplete and besides, relationship between Wnt signaling and PLD is not known.
Annexin A2 has been implicated in progression, migration and metastatic potential (Gillette et al, 2004; Hayes and Moss, 2004).
Activation of the PI3K/Akt pathway has been implicated in progression and drug resistance of human MM.
Adamts4 is one of the main aggrecanases responsible for remodelling the aggrecan network in articular cartilage and has been implicated in progression of osteoarthritis [ 65].
Moreover, the cellular profile of DNA hypermethylation has been implicated in progression and metastasis of lung cancer (Nakamura et al, 2003; Shimamoto et al, 2004).
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ECM remodeling by myofibroblasts is implicated in progression of prostate cancer xenografts (Verona et al. 2007).
Moreover, ICAM-1 is implicated in progression of vascular atherosclerotic disease (22).
Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas.
CD81 has also been shown to regulate cell migration and invasion, and has therefore been implicated in cancer progression.
Pro-inflammatory cytokines have been implicated in ALD progression due to pro-apoptotic effects on hepatocytes.
More suggestions(13)
been implicated in plaque
been implicated in neuroinflammation
been implicated in acne
been implicated in plant
been implicated in arthritis
been implicated in insulin
been implicated in atherogenesis
been implicated in cancer
been implicated in cholesterol
been implicated in atherosclerosis
been implicated in fraud
been implicated in skin
been implicated in diabetes
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