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Thrombomodulatory factors have been implicated in plaque instability.
Specifically, the cumulative upregulation of (1) a matrix metalloproteinase gene that has previously been implicated in plaque rupture, (2) potassium channel genes involved in membrane potential maintenance and action potential generation, and (3) sphingolipid and ceramide metabolism-related genes, together give cause for concern over rosiglitazone's safety.
Matrix Metalloproteinases (MMPs) are a family of extracellular matrix degrading enzymes which have been implicated in plaque destabilisation [ 10].
These beneficial/pleiotropic effects of statins have been suggested in various disease processes: statins have been implicated in plaque stabilization (14), reduction of inflammation (as noted by a reduction in C-reactive protein [CRP] levels) (15), reversal of endothelial dysfunction (16), and decreased thrombogenicity (17).
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Considering that T. denticola resides in infected gingival tissue prone to bleeding and has been implicated in atherosclerotic plaque buildup, adaptation to blood-rich environments is likely.
Orally administered curcuminoids have been implicated in reducing Aβ plaque burden and the amount of soluble Aβ in Alzheimer transgenic mice [ 20].
In nonlupus models, IL-17 has been implicated in the development of atherosclerotic plaques.
In addition, CCL2 has also been implicated in monocyte infiltration into atherosclerotic plaques and exacerbation of atherosclerosis [ 27].
VEGF/VEGFR signaling has been implicated in the development of atherosclerosis and plaque vulnerability [8]-[14] partinulassociationociation with diabetes [15]-[17] [15]-[17]
Among these immune cells, blood-derived cells and their infiltration into the CNS towards Aβ plaques have been implicated in therapeutic strategies against AD.
Activated microglia associated with A β plaques have been implicated in the phagocytosis of cerebral A β, with reports indicating that these cells may be involved in the stabilisation or clearance of A β plaques in the brain.
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been implicated in autophagy
been implicated in epilepsy
been implicated in mechanotransduction
been implicated in schizophrenia
been implicated in oncogenesis
been implicated in type
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been implicated in inflammation
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been implicated in neuroprotection
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been implicated in invasion
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