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BET proteins have also been implicated in physiological processes such as inflammation17, 27, 28, hematopoiesis29, 30, oligodendrocyte differentiation31, adipogenesis32, spermatogenesis33, keratinocyte differentiation34, and memory formation35.
Hydrogen sulfide (H2S) signaling has been implicated in physiological processes in practically all organ systems studied to date.
Since their discovery, endocannabinoids, anandamide and 2-AG in particular, have been implicated in physiological functions as well as in many pathological conditions.
sPLA2 enzymes have been implicated in physiological functions, host defence and inflammation.
Consistent with these in vitro findings, TRPV4 has been implicated in physiological functions such as osmoregulation and thermoregulation.
The endfoot pool of AQP4 represents an influx route of water in brain edema (Amiry-Moghaddam et al. 2003), but also has been implicated in physiological functions including water resorption postnatally (Haj-Yasein et al. 2011).
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Cathepsin S is a lysosomal cysteine peptidase of the papain superfamily which is implicated in physiological and pathological states.
The hippocampus is implicated in physiological learning and memory, as well as in the cognitive dysfunction seen in some PD patients where there is an interaction with the dopaminergic system [ 154].
EMT is implicated in physiological processes, such as embryonic development and wound healing, and in pathological processes, such as the progression of early-stage non-invasive tumors to invasive malignancies and fibrosis.
These findings reveal the presence of a physical and functional connection between mitochondria and the secretory/endocytic pathway that for the first time does not involve the ER and is implicated in physiological and pathological organelle biogenesis.
Nitric oxide (NO) has been implicated in multiple physiological and pathological immune processes.
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