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In addition, components of the limbic system, such as amygdalae, have been implicated in persistent pain.
In locomotion, reciprocal excitation among reticulospinal neurons has even been implicated in persistent tactile-induced swimming (Li et al., 2006).
PPARG agonists exhibit anticancer activity in glioma models [ 50], and increases in PPAR function have been implicated in persistent inflammation [ 51], while agonists of LXR promote glioblastoma cell death [ 52].
As for the postsynaptic effect, it is already reported that activation of NMDAR is important for initiating long-lasting changes in synapses and has been implicated in persistent pain by strengthening glutamatergic sensory transmission.
L-form bacteria are atypical, pleomorphic cell wall-deficient forms that are formed as part of the life cycle of stressed bacteria and have been implicated in persistent infections.
S. aureus small colony variants have been implicated in persistent and recurrent infections that give a poor clinical and bacteriologic response to standard antimicrobial therapy in patients with abscess, chronic osteomyelitis, and bronchopulmonary infections, particularly after prolonged exposure to antibiotics (1 – 6 ).
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Heavy drinking is a significant risk factor for health consequences, and is implicated in persistent smoking and less success at quitting smoking.
Many causal mechanisms that are thought to be implicated in persistent pain and a single intraoperative intervention might not be sufficient to decrease its occurrence.
If perspective-taking is important for engaging in intentional moral conduct [ 3], or for facilitating social functioning [ 4], it is likely that deficits in the ability to understand another's cognitive and affective perspectives may be implicated in persistent antisocial conduct.
EAEC isolates have been implicated in acute and persistent sporadic diarrhea, and outbreaks, in both industrialized and developing countries (reviewed by [2], [3], [4]).
Addiction to drugs (and alcohol) is characterized by compulsive drug taking and seeking, and the dorsal striatum has been implicated in such maladaptive persistent habits.
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