Furthermore, accumulation of the plant stress response molecules proline and gamma-aminobutyric acid, which have also been implicated in pathways leading to 2-AP production, was assessed to study shading effects on these compounds in fragrant rice, and to further possibly determine fluxes in biochemical pathways leading to 2-AP accumulation.
Another candidate gene that has been implicated in pathways influencing lipids, glucose metabolism and possibly cognition is APOC3, which encodes apolipoprotein C-III [3], [9].
HPr has also been implicated in pathway-specific activation or repression.
Interestingly, chromosome segregation defects have recently been implicated in pathways of early aging and senescence (80– 80).
Cx43 has previously been implicated in pathways that affect regulators of the cell cycle such as cyclin D1 [ 36].
Many of the proteins identified have been implicated in pathways thought to contribute to the physiologic homeostasis of cartilage, synovial tissue, and SF.
All of these genetic loci, apart from the less studied TSPAN8, have been implicated in pathways primarily involved in insulin secretion, cell proliferation and regeneration [ 30].
Although AEG-1 is an oncogene that has been implicated in pathways critical to lung cancer carcinogenesis [ 15], AEG-1 was also found to control the expression of E-cadherin and Vimentin [ 16].
Overall, the biochemical and morphological evidence supports the view that SEL1L p38 and p28 are implicated in pathways linking ER stress/UPR to endosomal trafficking and to secretion via extracellularly-shed vesicles.
PARP1 is a known key facilitator of DNA repair and is implicated in pathways of carcinogenesis.
These included genes were implicated in pathways important to drotrecogin alpha, vasopressin, hydrocortisone and norepinephrine.
