Sentence examples for been implicated in pathological from inspiring English sources
Hyperglycemia-induced oxidative stress has been implicated in pathological condition in which nicotinamide adenine dinucleotide phosphate oxidase is a major source of reactive oxygen species (ROS) generation35.
Hepatic mitochondrial dysfunction has been implicated in pathological conditions leading to non-alcoholic steatohepatitis (NASH).
VILIP-1 has been implicated in pathological processes of the nervous system such as Alzheimer's disease and Schizophrenia [1], [2].
However, in addition to their beneficial role in an acute stress response, both stress and CRF have been implicated in pathological disease states, including drug addiction.
Fusion of placental villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of successful pregnancy, and disturbances in this process have been implicated in pathological conditions such as pre-eclampsia and intra-uterine growth retardation.
Hyperactivation of KLKs (mainly KLK5 and KLK7) in epidermis has been implicated in pathological over-desquamation, a symptom common to a number of skin diseases, including atopic dermatitis and Netherton syndrome (NS) a rare syndrome of severe ichthyosis caused by mutations in Spink5 gene that encodes LEKTI, a multidomain inhibitor of KLKs and other serine proteases [62].
Activation of peroxisome proliferator-activated receptor alpha (PPARα) occurs in animal models of diabetes (DM) and is implicated in pathological responses to myocardial ischemia.
The Twist1-family basic helix-loop-helix (bHLH) transcription factors including Twist1, Hand1 and Hand2, play an essential role in heart development and are implicated in pathological heart remodeling.
Platelets are implicated in pathological processes typically due to inappropriate or excessive activation of normal platelet physiological processes.
Ccl2 mRNA expression has recently been shown to increase in all forms of AMD (Newman et al, 2012) and the CCL2/CCR2 axis is implicated in pathological inflammation and photoreceptor degeneration in chronic photo-oxidative stress (Suzuki et al, 2012), in carboxyethylpyrrole-immunization-induced retinopathy (Cruz-Guilloty et al, 2013), and in a model of retinitis pigmentosa (Guo et al, 2012).
