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The remaining expanded families included those encoding tyrosinases, galatose oxidase precursors and transmembrane receptors, all of which have been implicated in pathogenic life styles [ 26, 66, 75].
Histone modification and, frequently, concomitant methylation have been implicated in pathogenic expression of tumor-related genes, and thus chromatic remodeling represents another potentially detectable biomarker for cancer [ 42].
Recently, two phosphodiesterases, UmPde1 and UmPde2, also acting on the c-AMP-dependent PKA pathway, have been implicated in pathogenic development as well as dimorphic growth control (Agarwal et al., 2013).
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Describing the structures along the folding landscape is of key importance to comprehend the folding reaction, design new proteins and to understand how several polypeptide chains are implicated in pathogenic amyloid states.
OPN regulates inflammation and is implicated in pathogenic maladies resulting from chronic obesity.
Among these insertions, called genomic islands (GIs), there are some that are implicated in pathogenic interactions, and are thus assumed to be a characteristic of clinical isolates.
Although U. urealyticum has been implicated in more pathogenic cases, inconsistent findings exist as to which Ureaplasma species is the most pathogenic.
More recently, Sn has been implicated in diverse pathogenic processes including rhinovirus infection [14] and porcine reproductive and respiratory syndrome virus infection [15].
The cell wall is an essential and dynamic fungal structure that has been implicated in several pathogenic processes.
While B. extructa's association with human periodontal disease is well documented, the bacterium has so far not been implicated in other pathogenic processes.
In plant pathogenic fungi and oomycetes, the expansion of a plethora of gene families such as peptidases, glycoside hydrolases, kinases, or transporters has been implicated in the pathogenic lifestyle [ 38– 44].
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