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If you take the gene we identified, this EphB2 gene - this is a gene that has also been implicated in particular types of cancers.
Genes affecting DNA repair processes have been implicated in particular because DNA is a direct target for ionizing radiation in the cell.
A role for TRAIL has been implicated in particular types of cellular differentiation such as colonic epithelial cells through a reciprocal expression relationship with PKCε.
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To test the underlying assumption that missing genes may be implicated in particular biological pathways, we examined their functional annotation in the context of Gene Ontology (GO) using the program GO Tree Machine [ 31].
This protein is an important pro-inflammatory molecule that has been implicated in cancer, in particular, in helping cancer cells to migrate to other tissues.
This gene has been implicated in numerous diseases, in particular BBS and isolated blindness (52).
Arginine methylation of TRF2, a shelterin component, has recently been implicated in telomere function, in particular in repressing premature sense-cence in primary cells [ 36].
Members of the kallikrein large family that belongs to serine-type proteases have been implicated in autoimmune diseases, in particular in a model of Sjögren's syndrome [ 37].
DLPFC has also been implicated in proactive control, in particular the active maintenance and updating of current goals, and use of this to adjust behavior (Braver and Barch 2006; Braver et al. 2007).
Their hyperactivation has been implicated in several diseases, in particular in the development of cancer.[ 417] Coactivator proteins bind the receptor through a so-called nuclear receptor box (NR-box) consisting of a LXXLL motif which adopts an α-helical secondary structure upon binding.
Many intracellular signalling proteins have been implicated in cell migration, and, in particular, Rho GTPases are known to contribute to multiple cellular processes that affect cell migration [ 3].
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