ANG-2 has been implicated in the organization of the lymphatic system through the activation of the Tie-2 receptor.
Glutamate and pharmacological modulation of the metabotropic glutamate receptors (mGluR) signaling have been implicated in the organization of vigilance states.
These proteins have been implicated in membrane organization, membrane-cytoskeleton contacts and vesicular transport.
Finally, Rho1 interacts with the protein Bni1p which has also been implicated in actin organization and is involved in polarized exocytosis [20] [24].
In addition to their role as transport channels, NPCs have been implicated in chromatin organization and gene regulation [ 4].
Calpains are Ca2+-regulated cysteine proteases that have been implicated in cytoskeletal organization, cell proliferation, apoptosis, cell motility, and hemostasis.
In addition to its well-studied role in cargo transport, cytoplasmic dynein has been implicated in the organization of the MT cytoskeleton itself, particularly during cell division.
We note, however, that other endocytic proteins, including clathrin itself, have been implicated in the organization of mitotic scaffolds (Royle, 2013; Kaur et al., 2014).
Proteins of the nuclear lamina, INM, and NPC interact with chromatin during interphase and have been implicated in chromatin organization at the envelope.
This may be particularly relevant to the zebrafish C-division as PTEN has also been implicated in the organization of lumenal membrane in MDCK cysts in culture [ 15], and PTEN associates with Bazooka (the Drosophila homologue of Pard3) at the apical membrane of fly epithelia and neuroblasts [ 16].
