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As CREB functioning has been implicated in neuronal activity[21], basal CREB activity may reflect the level of activated neurons in the mouse brain under unstimulated conditions.
The enzyme caspase-1 has been implicated in neuronal death.
This phenomenon has been implicated in neuronal differentiation, long-term potentiation, seizures, and disorders of neural plasticity such as Rett syndrome and epilepsy.
The primary protein components of these two histopathological features, β-amyloid peptide (Aβ) and tau, respectively, have been implicated in neuronal death.
The P13K-AKT pathway, upregulated on SLActive surfaces (in relation to angiogenesis), has also been implicated in neuronal survival and subsequent neural development [77,78] and could have contributed to upregulation of neurogenic genes at these surfaces.
Dendritic filopodia have been implicated in neuronal contact formation and spine development [2], [8], [34], [35], [38], [39], [40].
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PAPC, FLRT3 and RND1 are all expressed in other tissues that all express various classical cadherins, including neurons, and are implicated in neuronal morphology and activity [17], [21], [22], and it will be important to examine their functional interactions in the regulation of cell adhesion in these other tissues.
This contrasts with chronic damage where overactivation of NMDA-Rs is implicated in neuronal death.
Gao, FB, and Keene, JD. "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation". Journal of Cell Science 109 ( Pt 3) (March 1996): 579-589.
Among its targets, the Ca2+/CaM-dependent protein kinases I and IV (CaMKs) are capable of transducing intraneuronal signals, and these kinases are implicated in neuronal gene regulation that mediates synaptic plasticity in mammals.
Ependymin II is a brain glycoprotein and is implicated in neuronal regeneration [60].
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