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Notch signaling has also been implicated in neural crest and valve development [9], [12], [16].
eIF4AII has been implicated in neural patterning where it has been proposed to up-regulate a subset of mRNAs based on their 5' UTR structure [37].
Thirty of the 141 SSTF target genes have already been implicated in neural tube development and 85 were predicted active nodes [19].
Neurogenesis in the dentate gyrus of the adult hippocampus has been implicated in neural plasticity and memory, but the molecular mechanisms controlling the proliferation and differentiation of newborn neurons and their integration into the synaptic circuitry are still largely unknown.
Although BMP inhibition has been implicated in neural induction, non-neural cells cannot respond to BMP antagonists unless previously exposed to a node graft for at least 5 hours before BMP inhibitors.
For example, Rho signaling has been implicated in neural tube closure [3] and cardiac morphogenesis [4] during vertebrate embryogenesis, whereas Rac signaling is critical for neurite outgrowth in vertebrates, worms and flies [5]-[7], and Cdc42 signaling plays similar roles in neurite outgrowth and axon guidance in vertebrates [8], [9].
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Furthermore, Snf2h forms a complex with Wstf and is implicated in neural progenitor cell proliferation, while Snf2l has gene-specific effects during neuronal terminal differentiation [75].
Furthermore, Otx2 is implicated in neural plasticity of PV-IR neurons in the postnatal visual cortex [ 30] and in axonal navigation and shaping neuronal arbors [ 60, 68].
Some JmjC KDMs are implicated in neural development and/or function and are associated with conditions including X-linked mental retardation, autism and midline defects [41 44].
It is of importance to investigate whether Dock7 regulates the function of TSC1/2 and whether such regulation is implicated in neural developmental diseases.
Due to the complexity of these morphogenetic movements, several hundred genes were implicated in neural tube closure in mouse genetic models (Harris and Juriloff, 2007).
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