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Like NCS-1, IL1RAPL1 has been implicated in nervous system development [27], and in particular in neurite outgrowth and differentiation [26], [28].
This pathway has been implicated in nervous system disorders such as depression in genomewide molecular pathway analyses [ 58, 59].
Many of the deleted genes have previously been implicated in nervous system development by studies in humans and mice (Table 1).
Many other genes deleted in the present case have been implicated in nervous system function and probably contribute to developmental delay, epilepsy, and related neuropsychiatric problems in monosomy 1p36 (Table 1; Additional file 1).
We also found the specific transcription factors spalt related (salr) (Mollereau et al., 2001), lethal of scute (l[1]sc) (Martin-Bermudo et al., 1991), retinal homoebox (Rx) (Davis et al., 2003), and longitudinals lacking (lola) (Giniger et al., 1994), which have previously been implicated in nervous system development.
Both proteins are putative transcription factors that have been implicated in nervous system development (Hu et al, 1995; Takasu-Ishikawa et al, 2001; Sugimura et al, 2004); moreover Apt was detected to be expressed in adult MBs (Kobayashi et al, 2006) and Ab was confirmed as a let-7 target in vitro and in vivo (Burgler and Macdonald, 2005; Caygill and Johnston, 2008).
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They selected around 30 genes that are implicated in nervous-system development and looked at which other genes regulate them, as well as the cell signals they in turn control.
11 Nel-like2 is predominantly expressed in the nervous system and has been implicated in neural development.
As the melanocortin signaling pathway has been implicated in sympathetic nervous system activity through β-ARs and WAT metabolism, our studies suggest a link between transcriptional regulation of melanocortin pathway genes by Nhlh2 and downstream peripheral effects leading to abnormal adipose functioning.
SFSV have infrequently been implicated in central nervous system infections.
N-myc Downstream Regulated Gene 2 (NDRG2) is a member of a recently identified gene family which has been implicated in human nervous system disorders and cancer [ 1].
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