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Sunitinib has previously been implicated in modulating calcium handling in cardiomyocytes, this ultimately impacts the ER50.
A number of factors have in fact been implicated in modulating neurogenesis [29] [36].
Particularly pertinent to the present study, the PVT has recently been implicated in modulating the reinstatement of alcohol seeking.
Moreover, Zic factors have also been implicated in modulating the transcriptional activity of Gli factors as well as in binding Gli binding sites in the chromatin [90].
All three well-characterized categories of MAPKs (ERKs, JNKs, and p38) have been implicated in modulating Nrf2, with some contradictory results among different groups.
Regulation of TP signaling itself is similarly complex, with multiple kinase-mediated pathways implicated in receptor desensitization, while oligomerization of the distinct TP splice variant products has also been implicated in modulating function [8], [9].
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Together with anatomical and behavioral results revealing a role for CRF1-R activity in the BLA, a role for these neurons is implicated in modulating anxiety responses and aversive memories including the modulation of hedonic state [4], [50].
GSK3β has been known to dictate the activity of mitogen-activated protein kinases (MAPK 39,40,41, which are implicated in modulating renal inflammation and fibrogenesis42,43,44,45,46,47.
The molecular function of Ctf4, however, remains unclear, and it is intriguing to address whether Ctf4 is implicated in modulating the level of histone acetylation.
Peroxisome proliferator-activated receptors are nuclear receptors highly expressed in intestinal epithelial cells (IEC) and immune cells within the gut mucosa and are implicated in modulating inflammation and immune responses.
Moreover, xCT is implicated in modulating synaptic plasticity.
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