Sentence examples for been implicated in mitochondrial from inspiring English sources
Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways.
C-Myc inhibition leads to down-regulation of PCG-1β, a PPARγ-coactivator that has been implicated in mitochondrial biogenesis [24].
Since PINK1 appears to occur upstream of parkin in a signaling pathway [18] [22], and parkin has been implicated in mitochondrial biogenesis [32], we investigated whether over-expression of parkin could reverse the mtDNA depletion observed following PINK1-silencing.
In terms of function, both genes could play a role in AMD: HTRA1 is a serine protease [9] which may affect the turnover of the ECM (i.e. Bruch's membrane), while ARMS2 has been implicated in mitochondrial function and oxidative stress [17].
In addition, c-Myc has been implicated in mitochondrial biogenesis [ 10] and global miRNA expression [ 11].
The microtubules of the spindle have also been implicated in mitochondrial inheritance in higher eukaryotes.
SIRT1 is the most characterized among all sirtuins and is implicated in mitochondrial and metabolic homeostasis [21, 47, 50].
NAD+ levels decline with mitochondrial dysfunction and reduced NAD+/NADH ratio is implicated in mitochondrial disorders, various age-related pathologies as well as during aging.
Despite parkin being implicated in mitochondrial biogenesis [32], over expression of parkin could not reverse mtDNA depletion following silencing of PINK1.
This complex is implicated in mitochondrial genome stabilization, mitochondrial morphology, oxidative stress, and apoptosis [ 3, 4].
122 These genes are implicated in mitochondrial tumor suppressor pathways, and SDH mutations have been described in sporadic or familial pheochromocytomas or extra-adrenal paragangliomas.
