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Matrix metalloproteinases are enzymes that degrade extracellular matrix components and have been implicated in membrane rupture.
The cleavage of several other substrates, including gelsolin as well as the kinases ROCK-1 and PAK2, has been implicated in membrane blebbing, a classical morphological feature.
These proteins have been implicated in membrane organization, membrane-cytoskeleton contacts and vesicular transport.
This was initially intriguing, as V-ATPase subunits physically interact with SNAREs and the V-ATPase has been implicated in membrane fusion in other genetic model systems.
The 'twin-arginine repeat' or TAT pathway is involved in the secretion of folded proteins and has not been implicated in membrane insertion [18].
While the ESX1 secretion system and ESAT-6 have been implicated in membrane injury and LMP, and are clearly associated with Mtb virulence, we found that they are dispensable for macrophage cytolysis at high MOI.
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In addition to mPR α, PGRMC1 has been implicated in membrane-initiated progesterone signaling [ 56].
In addition to classical PRs, PGMRC1 (progesterone membrane receptor component-1) [ 3, 7, 8] has been implicated in membrane-initiated progesterone signaling.
It dephosphorylates the phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns 3,5 P2 and is believed to be implicated in membrane remodeling and transport.
Evidence that syntrophins are implicated in membrane traffic is supported by the finding that knockout of α1-syntrophin alters the perivascular localization of aquaporin-4-containing vesicles [31] [33].
Microtubules are implicated in membrane remodeling and polarized vesicle traffic, influencing the barrier and adhesive functions of TJ and AJ [13], [14], [15], [16].
More suggestions(18)
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been implicated in neuroinflammation
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been studied in membrane
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been implicated in insulin
been interested in membrane
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been implicated in diabetes
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