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We have focused on the canonical Wnt pathway, which has an established role in developmental processes, but has recently been implicated in mechanisms of neurodegeneration/neuroprotection in the adult brain [25] [27].
Oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain (Calabrese et al 2003).
The subthalamic nucleus (STN) has been implicated in mechanisms underlying perceptual decision making (Frank 2006; Fleming et al. 2010a, b; Simen et al. 2006; Bogacz and Gurney 2007; Bogacz 2007; Bogacz et al. 2010a; Cavanagh et al. 2011).
Periostin has been implicated in mechanisms of wound repair and collagen fibrillogenesis 10, 12, 14; thus, periostin deficiency with a concomitant decrease in TGF-β1 might have been expected to inhibit allergen-induced airway fibrosis.
Most of these miRNAs have been implicated in mechanisms of hepatocellular carcinoma (miR-193b, [ 13] -195, [ 14- 16] -200a/b [ 15, 17- 19]), hepatitis C virus infection of hepatocytes (miR-193b [ 20] and −320 [ 21]), and nonalcoholic fatty liver disease and steatohepatitis (miR-200a/b, [ 22, 23] Table 2).
The HBP has been implicated in mechanisms of glucose toxicity [ 33] and dietary glucosamine increases HBP flux in flies [ 34]. tub P >RNAi dHHEX flies proved glucosamine-intolerant: the addition of 0.1 M glucosamine to a control diet resulted in failure to pupariate.
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A number of amyloid diseases involve deposition of extracellular protein aggregates, which are implicated in mechanisms of cell damage and death.
Urokinase that also binds the RGG domain of nucleolin is implicated in mechanisms regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis [21], [24].
By blocking surface nucleolin, HB-19 could perturb signaling events during induction of cell proliferation in response to various stimuli, thus illustrating that surface nucleolin could be implicated in mechanisms that link extracellular signals with intracellular signaling [30].
Laminin-1 that induces differentiation of cells binds surface nucleolin, while urokinase that is implicated in mechanisms regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis binds and is co-internalized with surface nucleolin [14], [18], [19].
Urokinase that is implicated in mechanisms regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis binds and is co-internalized with surface nucleolin [ 17, 18].
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