Sentence examples for been implicated in malignant from inspiring English sources

Aberrant DNA damage responses and increased accumulation of DNA damage has been implicated in malignant transformation in the hematopoietic system.

Generally, members of both clusters have been implicated in malignant growth.

Stem cells isolated from several tumors have been implicated in malignant cell growth and metastasis.

Loss or gain of expression of specific integrin has been implicated in malignant transformation, tumour progression and metastasis (Mizejewski, 1999).

As activin A has previously been implicated in malignant progression, we focused the subsequent analysis on this member of the activin family.

Defective internalisation of ligand-activated EGFR leads to prolonged signalling and has been implicated in malignant transformation (Marmor and Yarden, 2004).

Heparanase has generated substantial interest as therapeutic target for antitumor therapy, because its activity is implicated in malignant behavior of cancer cells and in tumor progression.

Aberrations in the UPS are implicated in malignant transformation, intensifying efforts to exploit UPS as a potential anticancer strategy.

Several members of this family modulate cell growth and survival, and they are implicated in malignant disorders [ 70], although the functions of most of them are largely unknown.

These two types of variation are thought to be implicated in malignant transformations for many (if not all) types of solid tumors.

Expression of the epidermal growth factor receptor gene, HER2, which is implicated in malignant transformation, was also used to characterize the cell lines, as overexpression is reported on average in 20-30% of ovarian tumors and as high as 75% by a variety of techniques including ELISA, immunohistochemistry and RT-PCR [ 38- 41].