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Looking at the effect on Type I IFN production in CD8+ T cells with deficient SOCE may provide additional insight into the cytotoxicity of these cells, since IFNa has been implicated in maintaining the survival of memory CD8+ cells, which has direct implications for sustained antitumour immunity.
PRDM14 has been implicated in maintaining the undifferentiated ESC state [73].
The RecQ helicase family has been implicated in maintaining the fidelity of both mitotic and meiotic recombination.
The Pbx and Id families have also been implicated in maintaining stem cell function (Figure 5B, Figure S5d) [19], [20], [21], [22], [22].
As acidocalcisomes have been implicated in maintaining ionic homeostasis and regulating cell volume in Leishmania parasites [53], it is tempting to speculate that T. gondii P-gp present in these organelles may contribute to this regulatory function as well.
The PTEN and Akt pathway has recently been implicated in maintaining the SP phenotype in glioma stem cells and breast cancer stem cells [37], [38], probably through affecting the activity of ABCG2.
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PG-associated lipoprotein (Pal) is highly conserved in Gram-negative bacteria and anchors to the outer membrane through an N-terminal lipid attachment and to PG layer through its periplasmic domain, which is implicated in maintaining outer membrane integrity.
LCK is one of the SRC genes, which are implicated in maintaining pluripotency in mESCs [48], [49].
In addition, Sert and Vmat2 that are implicated in maintaining normal functions of 5-HTergic neurons were greatly reduced in Lmx1b iCKO mice.
The macrophage-derived immune-regulatory cytokine IL-27 is implicated in maintaining pulmonary homeostasis.
C. truncatum likely secretes an arsenal of proteins that are implicated in maintaining a compatible interaction with its host.
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