Sentence examples for been implicated in lymphocyte from inspiring English sources
The phosopholipid sphingosine-1-phosphate receptors S1P1 4 have been implicated in lymphocyte recirculation and tissue homing critical in adaptive immune responses [42].
Likewise, p73-deficient thymocytes contained altered mRNA levels of LFA-1 (integrin beta 2) and chemokine receptors CCR4, CCR7, CCR8, CCR9 and CXCR5 (Fig. 5B), which have been implicated in lymphocyte migration and dissemination [25].
Protein kinase D (PKD) has previously been implicated in lymphocyte integrin regulation through regulation of Rap1 activity.
Over-expression of PD1, which has been implicated in lymphocyte exhaustion with chronic viral infections [ 98], has not yet been described.
In addition to its role in cancer, ATX LPA signaling has been implicated in lymphocyte homing and (chronic) inflammation, fibrotic diseases, thrombosis, and cholestatic pruritus.
Members of the evolutionarily conserved family of the chicken ovalbumin upstream promoter transcription factor NR2F/COUP-TF orphan receptors have been implicated in lymphocyte biology, ranging from activation to differentiation and elicitation of immune effector functions.
Furthermore, p73-deficient thymocytes exhibit altered mRNA levels of chemokine receptors such as CCR4, CCR7, CCR8, CCR9, and CXCR3, which have been implicated in governing lymphocyte migration and dissemination [25].
In particular, we were interested in whether receptor ligand pairs that had been implicated in inhibiting lymphocyte function were upregulated over time.
The PKC and PKD families of protein kinases have previously been implicated in regulation of lymphocyte integrins; however, the role of PKD in these events has not previously been clarified in primary lymphocytes.
For instance, cell surface glycoproteins are important in cellular recognition and have been implicated in embryonic development, lymphocyte trafficking, and cancer metastasis, and there is resurging interest in glycoconjugates as therapeutics.
Non-apoptotic functions of Fas-associated protein with death domain (FADD) have been implicated in T lineage lymphocytes, but the nature of FADD-dependent non-apoptotic mechanism in early T-cell development has not been completely elucidated.
