Sentence examples for been implicated in longevity from inspiring English sources

The mTOR pathway has been implicated in longevity in model organisms such as yeast, worms and flies.

Similarly, branched chain amino acids have been implicated in longevity of higher eukaryotes [ 34, 35].

Orthologs of genes that function downstream of Ras in yeast have also been implicated in longevity extension in mice.

The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy.

Of the genetically determined pathways that have been implicated in longevity in a variety of different model organisms, the evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway clearly stands out in current literature (reviewed in [ 6]).

Manipulations that extend lifespan often increase stress resistance at the cellular level, and a number of factors that play a role in the stress response have also been implicated in longevity.

"We found using this approach really narrows down the number of locations genome-wide that are implicated in longevity," said Molly Burke, a postdoctoral researcher at UC Irvine.

Airn is likely involved in aging and senescence through its effect on IGF2R, since senescent cells show enhanced IGF2R expression compared to proliferating cells and IGF2R is implicated in longevity [ 46, 47]; however, a role for Airn in these age-related processes has not been studied directly.

As mammalian apoptosis has been implicated in regulating longevity (Biteau et al., 2011; Raffaello & Rizzuto, 2011; Rufini et al., 2013), loss of cells due to the activation of the intrinsic pathway of apoptosis mediated through TSPO would seem to be central to longevity.

Dopamine has also been implicated in mammalian longevity; mice fed the drug levodopa (L-DOPA), which is expected to potentiate dopamine levels, had significantly longer lives (up to 50% longer), whereas Dopamine Receptor 4 (DRD4) mutants show reduced lifespan when the animals were kept in an enriched environment.

It is unknown whether C. elegans LIN-3/EGF signaling activates PI3K (AAP-1, PDK-1, and AGE-1 in C. elegans) or Akt (AKT-1 and AKT-2 in C. elegans); however, Insulin/IGF Signaling (IIS) has been implicated in regulating longevity through PI3K and Akt [ 30].