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Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins.
Although several signalling pathways have been implicated in liver formation1,2, so far no single gene has been identified that exclusively regulates liver specification.
Mutations in a gene called M6P/IGR2R have previously been implicated in liver cancer.
However, neither BRN-2, nor PAX-6 have previously been implicated in liver regeneration.
Dysregulation of the IGF axis has been implicated in liver tumor formation and progression (Scharf et al. 2001).
In addition to Bmp and Fgf signaling, Wnt signaling has relatively recently been implicated in liver specification.
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Module B (-80 to -40) overlaps with a protected region in DNAse footprinting in rat liver [ 22] as well as in HepG2 cells [ 23], and contains a HNF1 binding site that has been implicated in liver-specific expression of the human HL gene by other groups [ 22- 24].
Interactions between hepatic stellate cells and endothelin-1 are implicated in liver fibrosis.
The results of this study indicate that 5-HT7 receptor is implicated in liver regeneration after partial hepatectomy.
The autonomic nervous system, both sympathetic and parasympathetic, is implicated in liver regeneration although the exact mechanisms of its effects still remain obscure [ 21- 23].
Liver is important for generating endogenous SM and regulating the SM levels in the plasma (Nilsson and Duan, 2006), and previous studies have shown that SM metabolism is implicated in liver diseases.
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