Several publications have indicated that caspase inhibitors are ineffective in blocking neutrophil apoptosis, and have concluded from this that caspase independent apoptosis pathways are implicated in limiting neutrophil lifespan [22], [23], [30].
Several studies have previously shown that transferrin is induced upon challenge [ 25, 35]; this protein seems to be implicated in limiting bacterial growth by sequestering iron [ 35].
The phenotypic analysis of MtN5-silenced roots showed that MtN5 is implicated in limiting root hair curling and that this role is necessary for an efficient colonization of nodule primordia.
HIV-1gp120 has been implicated in immune dysregulatory functions that may limit anti-HIV antigen-specific T cell responses.
Likewise, the decreased expression (4.28 fold) of thrombospondin 1 (THBS1), as observed in senior dogs fed APB, may also indicate the predisposition of the liver to inflammation and fibrosis with age because THBS1, a mediator of TGF-β signaling pathway, has been implicated in attenuating inflammatory response and fibrosis by limiting angiogenesis in the heart [40].
For example, Arabidopsis thaliana glycine-rich RNA-binding proteins 7 and 8 (AtGRP7 and AtGRP8 which share 65%and63%3% sequence identity with HvGR-RBP1) have been implicated in numerous biological processes including but not limited to circadian clock-controlled mechanisms, plant pathogen defense, and plant flowering control, in addition to a possible role in senescence.
AVA have been implicated in the development of cardiac allograft vasculopathy (CAV), limiting the long-term benefits of cardiac transplantation.
A variety of host-cell factors, particularly cytoskeleton components, and viral proteins have been implicated in RSV filament formation, however our understanding of their mechanistic role is limited.
Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury.
ATGL, the rate-limiting enzyme in TG catabolism, has also been implicated in retinoid homeostasis.
