Sentence examples for been implicated in leukemogenesis from inspiring English sources

Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic regulatory DNA elements.

Importantly, Stat5 has been implicated in leukemogenesis, and expression of constitutively active Stat5 in hematopoietic cells has been shown to induce a rapidly fatal myeloproliferative disease in mice [36] [38].

The formation of MCF recombinants has been implicated in leukemogenesis by several MLVs.

The miR-29 family members have been implicated in leukemogenesis; however, their role is not well established.

In line with such notions, several miRNAs such as miR-15a, miR-16-1, miR-155 miR-17-92 miR-17-92 miR-17-92en impliclustern leukemogenesis and lymphavegenesis.

In particular, Shp2 has been shown to play a critical role in regulation of hematopoietic stem cell commitment and differentiation into all blood cell lineages, and somatic gain of function mutations in PTPN11/Shp2 are implicated in leukemogenesis in human patients [22] [26].

HIFs regulate crucial aspects of solid tumor progression and are currently being implicated in leukemogenesis.

Recently, a Blast search confirmed that two leukemia-associated genes, LCX and MLL, containing the CXXC-zinc finger motif is homologous with xIdax, implying that Idax in human might be implicated in leukemogenesis.

5, 6 In addition, the involvement of systemic downregulation of cellular microRNA has been implicated in the leukemogenesis of ATL.

Two genes that have been implicated in ESC, kidney development and leukemogenesis, PTEN and SALL1, were identified as potential SALL4 downstream target genes.

Calcium signaling has been implicated in plant graviperception.