Sentence examples for been implicated in large from inspiring English sources

In Germany and Canada, STEC has been implicated in large outbreaks as well as in sporadic cases of hemorrhagic colitis and HUS [ 29- 31].

Viruses of lower vertebrates are abundant worldwide and have been implicated in large losses in wild fish and amphibian populations, as well as in those raised in commercial farms [ 40, 59, 62].

ISs have been implicated in large changes to genome structure, by expanding in copy number in microbial genomes, with subsequent loss of ISs resulting in inactivation of genes, pseudogene formation, mediating deletion of intervening sequences between two copies of the IS, or rearrangements of the genome [ 3].

Complex lifestyles are implicated in large genomes with diverse signaling capability, and in general genomes with a very large number of annotated open reading frames (orfs) have high numbers of predicted signal transducing proteins, as shown in Fig. 3, though some species, such as Rhodococcus RHA1 and Psychroflexus torques are notable exceptions to this trend.

Altered Bcl-2 biology has been implicated in a large number of cancer cells, including B-cell lymphomas like diffuse large B-cell lymphoma (DL-BCL) and chronic lymphocytic leukemia (CLL).

The cytochrome P450 (CYP450) family of enzymes has been implicated in a large number of preventable, adverse drug interactions when individually discussing HIV and psychopharmacology.

Polyamines have been implicated in a large number of cellular processes, including functioning of ion channels, nucleic acid packaging, DNA replication, apoptosis, transcription and translation [19].

Mutations in coiled-coil proteins have been implicated in a large variety of human diseases such as severe skin fragility, muscular dystrophies, neurodegenerative diseases, progeria, and cancer [ 3- 10].

The importance of this signaling mechanism is becoming more widely recognized as steroid membrane receptors have been implicated in a large number of physiologic functions.

The transcription factor activator protein-1 (AP-1) has been implicated in a large variety of biological processes including oncogenic transformation.

Only recently discovered, they represent a new class of ncRNAs that have also been implicated in a large spectrum of biological processes.