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Cyclic ADP-ribose-mediated calcium signals have been implicated in key events such as fertilization of sea urchin eggs [61], [62] and insulin secretion from pancreatic beta cells [63].
First identified in Caenorhabditis elegans[ 5], miRNAs have been implicated in key aspects of cellular, developmental, and pathophysiological processes.
These segments have been implicated in key mechanistic elements of NSS function including regulatory phosphorylation and the actions of psychostimulants.
In fish and amphibians, proteins of the Nme family have been implicated in key developmental processes in the oocyte or embryo [ 16- 18].
One such factor, Snail, a master regulator of the epithelial mesenchymal transition (EMT), has been implicated in key tumour biological processes such as invasion and metastasis.
The PAG has been implicated in key neuronal processes; pain and analgesia, fear and anxiety, lordosis, cardiovascular control and vocalisation [ 56].
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Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity.
The mucin sugar moiety contains sialic acid that is implicated in key aspects of parasite-host interactions such as cell adhesion and invasion [4], and resistance to non-specific complement attack [5].
These genes are implicated in key biological functions depicted in Figure 2b and Table 2. Cluster C consists of 193 transcripts that, compared with age-matched WT mice, were upregulated in 3 m.o. and 12 m.o.o
In the stratum corneum, serine proteases from the kallikrein-related peptidase (KLK) family have been implicated in several key homeostatic processes, including desquamation.
Proteases and reactive oxygen species (ROS) have long been implicated in playing key roles in host tissue injury at sites of inflammation dominated by macrophage activations and/or neutrophil infiltrations.
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