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The speA gene has been implicated in invasive phenotypes.
Of note, the expression of miRNAs miR-520c and miR-373 is known to characterize stem cells and in terms of molecular oncology has been implicated in invasive growth of epithelial cells in vitro and in vivo thus allowing to delineate a distinct molecular subtype of thyroid adenomas.
S. lugdunensis has been implicated in invasive diseases, especially fulminant native and prosthetic-valve endocarditis [ 3].
Similarly, chemotherapy induced oropharyngeal mucositis [ 21, 22] and inflammatory bowel disease [ 23, 24] have been implicated in invasive F. nucleatum infection.
In addition to collagenases-1 and -3 that have been implicated in invasive growth behaviour of various malignant tumours, we analysed the levels of 72-kDa gelatinase and its activators MT1-MMP and TIMP-2 in cultured melanoma cells.
MRSA is becoming an important cause of skin and soft tissue infection in persons in the community (4, 5 ) and has also been implicated in invasive infections such as necrotizing pneumonia (6 ).
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VIM and CDH4 were implicated in invasive cancer (Additional file 8: Table S4B).
In line with the above, EMT drives tumour cells towards a more mesenchymal phenotype and is implicated in invasive and malignant behaviour.
For invasive tumors like ovarian cancers, Snail and MMP-9 expressions are closely connected since they have both been implicated in similar invasive processes [65].
C35 has recently been implicated in conferring invasive potential in prostate cancer cell lines (Dasgupta et al, 2009).
Indeed, sucrolytic activity by fungal GH32 enzymes has been implicated in the invasive growth of several plant pathogenic fungi.
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