The aPL have been implicated in reactions that interfere with almost all known hemostatic and endothelial cell reactions [ 2].
The transforming growth factor b1-stimulated clone 22 domain family member 3 (TSC22D, GILZ), which has been implicated in the immunosuppressive function of glucocorticoids by interfering with NF- κB-mediated gene transcription in T cells, was also induced by both GR isoforms (Supplementary Table 2 and Supplementary Figure 2).
As the PAFR has been implicated in other neurodegenerative disorders such as ischemia [62] and multiple sclerosis [39], interfering with PAFRs could be a therapeutic strategy widely applicable to central nervous system diseases.
In fact, cognitive mechanisms have been implicated in the neurobiology of depression and antidepressant response, since they might interfere with stress adaptation and biases in the processing of negative affect [ 60].
Glutamate has been implicated in the 'Chinese food syndrome', where food with high amounts of monosodium glutamate interfere with normal neurotransmission causing confusion [ 9].
Other negative regulators including NF- κB inhibitor interacting RAS-like (NKIRAS) 1 and 2, which interfere with proteosomal degradation of I κB, have also been implicated in regulating NF- κB activity, but their role in gliomas is poorly understood.
Glutamate has been implicated in the 'Chinese food syndrome', in which food with high amounts of monosodium glutamate interferes with normal neurotransmission causing confusion [ 39].
Furthermore, loss of desmosomal cadherins and associated proteins interferes with wnt/β-catenin signaling [ 18, 28], which has been implicated in DCM [ 26].
Both of these factors are thought to attenuate insulin action, in part, by activating pathways that interfere with or oppose insulin signaling and thus they have also been implicated in the development of obesity-induced IR [ 15– 17].
In S. cerevisiae, disomy of individual chromosomes in haploid strains has been implicated in various phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding (54).
