Sentence examples for been implicated in insulin from inspiring English sources

Abnormal overexpression of GSK3β has been implicated in insulin resistance.

In addition, CK2 has also been implicated in insulin signaling.

Increased expression of p85α has been implicated in insulin resistance as knockout of p85α improves insulin sensitivity in vitro [22] and in vivo [23].

While oxidative stress accumulates in adipose tissue and has been implicated in insulin resistance [31], the inherent mechanisms linking oxidative damage to adipose tissue dysfunction remain unknown.

In addition to PALD, a number of the confirmed screen hits have not previously been implicated in insulin signaling and are therefore putative novel inhibitors of insulin signaling.

DOK2 has also been implicated in insulin signaling by virtue of its similarity to IRS family members [20]; we now provide functional evidence for a role for DOK2 as an inhibitor of insulin action.

The serine/threonine kinase Akt2 has been implicated in insulin-regulated glucose uptake into muscle and fat cells by promoting the translocation of glucose transporter 4 (GLUto) thethe cell surface.

Although Rab10 has been implicated in insulin-stimulated GLUT4 translocation in adipocytes, the role of GDI in this process has not been addressed yet.

Vitamin D receptor (VDR a key mediator of the vitamin D pathway has been implicated in insulin-like growth factor signaling, inflammation, estrogen-related pathways, and activation and regulation of vitamin D and calcium.

Since PI3K/Akt signaling pathway has been implicated in insulin-mediated regulation of learning and memory function, we also investigated the expression of IGF-1, PI3K, Akt, and p-CREB in brain tissue of mice fed different diets.

Because AS160 has been implicated in insulin-stimulated glucose transport in muscle and fat cells (Sano et al., 2003; Thong et al., 2007) and also in glucose-induced insulin secretion from pancreatic beta cells (Bouzakri et al., 2008), we sought to determine if whole-body glucose homeostasis is altered in the knockin animals.