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Many of these gene families have been implicated in innate immunity [29], [30].
Lipocalin 2 has also been implicated in innate immunity, as Lcn2-deficient mice are more susceptible to bacterial infection [26].
The genes showing a strain by stage interaction display significant enrichment of genes that have been implicated in innate immunity (p = .00215).00215
In addition to the intracellular chaperone function, gp96 has been implicated in innate and adaptive immunity [20],[21] and its cell surface exposure is associated with its immunological activities such as the activation or maturation of dendritic cells (DCs) [22] [24].
PKCε has been implicated in innate immunity through its role in macrophage activation (Castrillo et al., 2001).
Most notably, LPS strongly induced expression of genes with AU-rich elements (m2/ARE), which have already previously been implicated in innate immunity [ 33, 34].
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Likewise, collaborative activation of dectin-1 with surface TLRs and/or other PRR may be implicated in innate sensing of different opportunistic fungi [45], [46].
While TREM1 is implicated in innate immune response as an amplifier of pro-inflammatory mediators such as IL-8, MCP1 and TNF-α [26], TNFAIP3 is part of the negative feedback regulatory mechanism of NF-κB and inhibitor of apoptosis [13].
Vitamin D may also be implicated in innate and acquired immunity.
NOD1 and NOD2 are two further NLRs that recognize PAMPs and are implicated in innate immune responses.
Tripartite motif proteins are implicated in innate immune response and some of them are involved in response to viral challenge [ 70].
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