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Auxin has already been implicated in initial leaf formation [ 58, 59], lamina margin elaboration [ 2, 3] and leaf vasculature patterning [ 60].
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Plasmepsin-2 is a malarial aspartic proteinase that has been implicated in the initial steps of hemoglobin degradation in parasites and thus represents an attractive antimalarial target.
Both ACE2 and ZPBP2 have been implicated in the initial binding of the sperm acrosome to ZP [35], [36].
The Rab11-recycling endosome has also been implicated in the initial targeting of newly synthesized E-cadherin to the basolateral plasma membrane, both in cultured mammalian cells [11], [12] and in the Drosophila pupal epidermis [13].
Dendritic cells (DCs), similar to skin-residing Langerhans cells, have been implicated in providing initial signals that break the immune protection of arterial walls [ 2, 3].
The water-transporting function of aquaporins has also been implicated in the initial formation of glial scars, affecting both the migration to the site of injury and the rate of glial scar formation [ Verkman, 2008) and references therein].
Several attachment factors, for example the microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and the surface-attached Atl protein, have been implicated in this initial stage of biofilm formation (reviewed elsewhere [ 82, 83]).
The detection of the called "enigmatic" family GH61 in P. chrysosporium and I. lacteus should also be pointed out, since proteins from this group have been implicated in the initial steps of lignocelluloses breakdown by white-rot fungi, disrupting the cellulose structure and enhancing its digestibility by cellulases in lignocelluloses [ 39].
Recently, several miRNAs have been implicated in regulating the initial step in epithelial-mesenchymal transition (EMT).
So far, the transcription factors Stat3 and Stat5a/b have been implicated in bcr/abl-induced initial transformation.
LTα has been implicated in inflammation since its initial description.
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