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The PI3K/mTOR pathway has previously been implicated in influencing fibroblast proliferative responses and TGF-β1-induced myofibroblast differentiation and collagen production20,21.
Both cell-mediated and antibody responses have been implicated in influencing the susceptibility, persistence or clearance of genital HPV infection.
Loop-1 has been implicated in influencing access to the nucleotide-binding site.
They have also been implicated in influencing mating success in both D. serrata [ 45– 47] and other insects [ 14, 33].
Both the WNT and TGF-β/BMP signalling pathways have been implicated in influencing bone mass and bone remodelling [ 32- 34] and have been demonstrated to do this by controlling both osteoblast and osteoclast differentiation and function [ 65- 67].
The immune system is known to play a key role: both cell-mediated immunity (CMI) and antibody production have been implicated in influencing the persistence or clearance of genital HPV infection [ 9].
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It is therefore possible that variation in the PAX6 expression level may be implicated in influencing the susceptibility to myopia development.
The approach used therefore allowed a very detailed analysis of this part of the PADI4 gene that was implicated in influencing RA susceptibility.
Indels have also been implicated in directly influencing functional differences between homologous domains [16].
Another candidate gene that has been implicated in pathways influencing lipids, glucose metabolism and possibly cognition is APOC3, which encodes apolipoprotein C-III [3], [9].
These variants have been implicated in gene expression by influencing transcription [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com