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They have also been implicated in inflammation and are connected to diverse diseases, such as cancer, ischemia, atherosclerosis, and schizophrenia.
These cytokines are abundantly present in the adipose tissue of ob/ob mice in vivo and have been implicated in inflammation and angiogenesis [6], [7] (See also Figure S6).
Interestingly, although PI3Kγ has clearly been implicated in inflammation in many other systems [7], wild type mice given either wild type or PI3Kγ−/− bone marrow developed comparable M I/R injuries (Figure 3A, C) and showed equal Troponin T release (Figure 3D).
LTα has been implicated in inflammation since its initial description.
Both Wnt5a overexpression and macrophage infiltration have been implicated in inflammation and cancer.
The human psoriasin (S100A7) gene has been implicated in inflammation and tumor progression.
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CD11b+ macrophages have also been implicated in inflammation-induced angiogenesis and lymphangiogenesis in a model of cutaneous leishmaniasis, based on in vivo depletion studies using clodronate liposomes.
Although macrophages are important in the host-defense mechanism, pathogen-induced overproduction of inflammatory factors from macrophages and cellular damage-derived inflammation-inducing molecules have been implicated in inflammation-related diseases, such as arthritis, inflammatory bowel diseases, and asthma [ 3].
Epithelial-mesenchymal transition is induced by the integrated actions of many stimuli including transforming growth factor-β and matrix-generated signals that are also known to be implicated in inflammation, repair responses, and fibrosis.
Thus, silver pyridoxine nanoparticles help macrophages secrete more IL-8, which is implicated in inflammation and postnatal wound-healing.
In addition, the lymphatic system is implicated in inflammation processes as well as cancer metastasis.
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