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Benzene, a ubiquitous environmental pollutant, has been long been implicated in induction of Acute Myeloid Leukemia (AML).
Strong activation of ERK has been implicated in induction of synaptic plasticity and consolidation of long-term memory.
Telomeres have also been implicated in induction of DNA damage leading to cell cycle arrest, either through senescence [20] or direct uncapping or TIFs (Telomere Dysfunction-Induced Focus) [21] [24].
Methylselenol has also been implicated in induction of caspase-mediated apoptosis in cancer cell lines.
Lead exposure has been implicated in induction of prenatal and postnatal induction of HSP70 in astrocytes [ 35].
It has been implicated in induction of PAR-2 (protease activated receptor -mediated IL-8 receptor -mediatedis vulgaris [ 21].
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Glu has been shown to be implicated in induction of cortical spreading depression (CSD), activation of trigeminal nociceptive neurons as well as play a role in central sensitization.
SOCS signaling is implicated in induction of IR [ 28- 30] and similarly it was found by us to be upregulated by LPS in adipose tissue ex vivo.
Repeated blood transfusions have been implicated in the induction and maintenance of sensitization.
Chronic HCV infection has been implicated in the induction and maintenance of B-cell lymphomas.
As such, catalysis of Aβ through metal interactions, glycoprotein binding and seeding have been implicated in the induction of auto polymerisation of nanomolar concentrations of the peptide, typically found in vivo40,41,42.
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