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Reduced levels of serotonin (5-HT) within prefrontal cortex (PFC amygdala circuits have long been implicated in impulsive aggression.
Serotonin [5-hydroxytryptamine (5-HT)] has been implicated in impulsive behaviours (Evenden, 1999; Cardinal et al., 2004).
Indeed, many psychiatric disorders associated with monoaminergic abnormalities feature social dysfunction [ 1, 11, 17], and interactions between serotonin and dopamine have been implicated in impulsive aggression [ 18] and psychopathy [ 19].
NK1R are also densely expressed on (cholinergic) interneurons in the striatum (Gerfen 1991), where they mediate the release of acetylcholine and dopamine (Galarraga et al. 1999), both of which have been implicated in impulsive behaviour (see Jupp & Dalley 2014; Moreno et al. 2013).
Third, we compared levels of impulsive responding across a series of mouse strains from the BXD series of recombinant inbred strains, and correlated levels of impulsivity with levels of expression of the snca gene in hippocampus, a brain area in which snca expression is prominent (Vivacqua et al. 2011), and which has been implicated in impulsive behaviour (Urcelay & Dalley 2011).
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Serotonin has been implicated in several forms of impulsive behavior, as well as in the etiology of Type II alcoholism.
The mPFC is densely innervated by serotonin (5-hydroxytryptamine; 5-HT) fibers in a distinct laminar organization (Linley et al, 2013), and 5-HT neurotransmission in the mPFC has been implicated in the control of impulsive action (Dalley et al, 2002) and cocaine-seeking (Bradberry and Rubino, 2004), particularly through the 5-HT2C receptor (5-HT2CR) (Pettkowski et al, 2010).
Since then, a whole system of genes has been implicated in making a person susceptible to impulsive, aggressive behaviour.
This brain area is involved in executive and impulsive control (Jurado and Rosselli 2007) and has been implicated in ADHD neuropathology (Faraone and Biederman 2002).
The noradrenergic system has also been implicated in the genesis and treatment of ADHD, yet little is known about the contribution this neurotransmitter makes to the regulation of impulsive behavior.
Calcium signaling has been implicated in plant graviperception.
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