TA class proteins represent 2.02% of all coding open reading frames in the human genome [30] and have been implicated in important aspects of cell physiology ranging from control of mitochondrial function, apoptosis and intracellular vesicular trafficking.
Cyclooxygenases (COX-1 and COX-2) convert arachidonic acid to bioactive prostaglandins (PG) and tromboxanes (TX), which have been implicated in important physiological functions [1], [2], as well as in the pathophysiology of several neurological and neurodegenerative diseases, such as stroke, epilepsy, and Alzheimer's disease [3].
CAF have recently been implicated in important aspects of epithelial solid tumor biology, such as progression, growth, angiogenesis and metastasis.
In essence, all of the TFs identified here have previously been implicated in important immune related settings [ 19- 26].
Cer, which is known to induce cell cycle arrest and has been implicated in important physiological roles in cell differentiation, senescence, migration, adhesion, and inflammatory responses, is the key intermediate in SL metabolism.
Boundaries been implicated in important cellular events, including differentiation (Handoko et al. 2011), genome imprinting (Chao et al. 2002), and cancer (Ceol et al. 2011; Fazi et al. 2007).
Their existence is thought to be implicated in important biological functions such as positive and negative transcription regulation or telomeric extension.
Despite being implicated in important cellular activities, few tetraspanins have been studied in detail, probably due to the difficulties imposed by their functional redundancy and subtle functions [17], [20].
Leaf size and shape are implicated in important aspects as thermoregulation [40], [41], efficiency of water use [23], [42], photosynthetic potential [43], branching and rooting strategies [44], among others.
Calpain activity is implicated in important cellular processes including cytoskeletal remodelling, apoptosis and survival.
