Sentence examples for been implicated in hereditary from inspiring English sources
Moreover, the genes that have been implicated in hereditary prostate cancers do not appear to be mutated in sporadic cancers.
The functions of the other two members of the SLC49 family, MFSD7 and DIRC2, are unknown, although DIRC2 has been implicated in hereditary renal carcinomas 447.
KIF1A/unc-104 has been implicated in hereditary spastic paraplegia (HSP) (Erlich et al. 2011; Klebe et al. 2012) and hereditary sensory and autonomic neuropathy type 2 (Riviere et al. 2011).
SNX10 is another PX-domain-only SNX protein which is able to regulate the subcellular distribution of vacuolar-type H+-ATPase (V-ATPase) [ 8] and it has recently been implicated in hereditary osteopetrosis in human [ 9– 12].
Two common polymorphisms in the HFE gene, the C282Y and the H63D, have been implicated in hereditary hemochromatosis, a disease associated with excess iron absorption (Feder et al. 1996; Hanson et al. 2001).
Spontaneous activation of the NALP3 inflammasome due to mutations in the NALP3 gene has been implicated in hereditary autoinflammatory syndromes such as Muckle Wells syndrome and chronic infantile neurologic cutaneous articular [ 11].
Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer.
First, FANCD2 and BRCA1/2 are functionally closely linked in the DNA repair response, and BRCA1 and BRCA2 are implicated in hereditary and sporadic breast cancers [ 21, 22].
Apart from being essential for normal development, the Notch signaling system has been implicated in human hereditary cardiovascular diseases and cancer [8], [9].
As many as 300 human genes are thought to be involved in the process of hearing [4] and to date, more than 100 mapped or characterized loci have been implicated in NSNHL (Hereditary Hearing Loss home page: http://webh01.ua.ac.be/hhh/).
