Sentence examples for been implicated in hepatic from inspiring English sources

Several miRNAs have been implicated in hepatic disease and proper hepatocyte function.

The signaling molecules bone morphogenic protein (BMP) and FGF that have been implicated in hepatic differentiation during normal embryonic development and have been shown to play pivotal roles in generating hepatic cells from DE cells derived from ESCs.

PI3K is the dominant signaling node responsible for insulin action, and a number of effectors downstream of PI3K have been implicated in hepatic lipid synthesis including Akt, PKC-ζ and PKC-λ [47].

5-LO pathway and LTs have been implicated in hepatic inflammation and liver damage.

Penta has been implicated in hepatic and endocrine-related effects after repeated exposure but has relatively low acute toxicity.

PPARA is a transcription factor that has been implicated in hepatic steatosis [ 40] and hepatic metabolic homeostasis through regulation of the hepatocyte nuclear factor-4 alpha (HNF4A) gene [ 41].

IGF-IR is implicated in hepatic carcinogenesis.

BMP4 is implicated in hepatic fibrosis and animal studies demonstrate increased BMP4 expression in activated hepatic stellate cells.

GABA activity, which typically depresses neuronal excitability, is implicated in hepatic encephalopathy and alcohol or benzodiazepine withdrawal [ 18].

48 Experimental studies of AGE administration in rodents confirm their increased liver tissue deposition parallel to an increase in the hepatic expression of RAGE and vascular endothelial growth factor (VEGF), which is implicated in hepatic fibrosis.

Plasma liver enzyme levels are commonly used as clinical indicators of liver damage and most of the candidate genes listed in Table 1 are implicated in hepatic steatosis and lipid or carbohydrate metabolism.