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Several genes have been implicated in heart tube formation, yet we know little about underlying cellular mechanisms.
Other significant pathways that have previously been implicated in heart development include ribosomal proteins [55], the actin cytoskeleton [52], Wnt signaling [56], and cytokine-cytokine receptor interaction [57].
Canonical pathways enriched within our genes of interest have previously been implicated in heart development and some of the pathways appear to be interconnected.
PKCε has been implicated in heart protection and ventricular hypertrophy.
Polymorphisms and abnormal enzymatic activity of PON1 have also been implicated in heart disease, osteoporosis, atherosclerosis, and cancer [ 23– 26].
In addition to the heart development, the RA signaling has also been implicated in heart regeneration in adult zebrafish.
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Indeed, total O-GlcNAc and protein O-GlcNAcylation are elevated in the diabetic heart [ 4, 39], but the functional implications of this finding are unclear as elevated cardiac O-GlcNAc is implicated in heart failure and cardiac dysfunction [ 39, 40], but also cardioprotection [ 41, 42].
Hand-holding was found to reduce levels of cortisol, high levels of which are implicated in heart disease and other chronic conditions.
Meanwhile, research has shown that when people with high LDL cholesterol (the "bad" kind) purge their diet of saturated fats, they lower one kind of LDL (the large, buoyant particles called "Type A" LDL), but not the small, dense particles ("Type B" LDL) that are linked to high carbohydrate intake and are implicated in heart disease.
SNP substitution E502K is implicated in heart disease [ 27].
Previous data suggest that decreased adiponectin expression may be implicated in heart failure progression in humans.
More suggestions(18)
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