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The rACC, which is innervated by DA, noradrenergic [47] and serotonergic [48] neurons has been implicated in generation or regulation of spontaneous internal thoughts, emotions, anxiety and in internal conflict resolution [49] [52].
The Vav family of guanine nucleotide exchange factors (GEF) has been implicated in generation of TCR signals and immune synapse formation, however, it is currently not known if Vav's GEF activity is required in T cell activation by the TCR in general, and in actin polymerization downstream of the TCR in particular.
MUS81 has been implicated in generation of ICL-induced DSBs [17].
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At the same time, cortico-cortical and thalamocortical networks are implicated in generation of alpha rhythms (8 12 Hz) [9], while beta rhythms are mostly generated in motor cortex.
Upregulation of LILRB4, whose ligand is expressed by T cells, could be implicated in generation of tolerized dendritic cells through the action of cytokines IL-10 and interferon-α [ 33].
Brain-derived neurotropic factor (BDNF) is a neurotrophin that has been implicated in the generation and modulation of pain [7].
Because of this, subthreshold resonance has been implicated in the generation of oscillations at the network level [23 27].
The unique pattern of connectivity changes found in inter-ictal MA patients involved area V3A which has been implicated in aura generation.
Because humoral alterations have been implicated in the generation and perpetuation of atrial fibrillation (AF), we aimed to elucidate possible abnormalities in atrial endocrine function in the setting of lone AF.
Subthreshold (membrane potential) resonance has been investigated in a number of neuron types both experimentally and theoretically [10, 12 22, 29, 40], and has been implicated in the generation of preferred neuronal firing rates [11] and network oscillations [23, 25, 27, 41 43].
Importantly, it has been implicated in the generation of intramitochondrial reactive oxygen species [20], [56].
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