The interaction between this region and the CTD might therefore be different in these two groups suggesting that this region may be implicated in functional specificity of type II topoisomerases, as the CTD plays a crucial role in DNA interaction.
Reorganization of chromosomal territories has been associated with changes in the epigenetic regulation of gene expression [ 11] and consequently may also be implicated in functional changes resulting from long-term culture of primary cells.
The structural data reveal a plasticity of the intermediate helix, which has been implicated in the functional cofactor dependency of many trypsin-like serine proteinases.
Hippocampal glutamate concentration has also been implicated in the functional coupling between frontal cortical and hippocampal regions during stimulus processing [25].
Noticeably, different intracellular signaling molecules such as kinases and adaptors, recruited through lipid rafts, have been implicated in PrPC functional interactions [3], [13], [20], [37], [41], [42].
Indels have also been implicated in directly influencing functional differences between homologous domains [16].
Importantly, the human orthologs of several these genes have been implicated in tumorigenesis, thus functional characterization of these genes is of great importance.
Vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) all have been implicated in MSC-mediated functional recovery of the heart after ischemic injury [5], [15], [16], [17].
These parasitic entities have been implicated in altering structural, functional and epigenetic variability of their host genome [ 13], consequently enhancing the evolvability of species and lineages.
Proinflammatory cytokines relevant to the pathogenesis of RA, such as interleukin-1β and tumor necrosis factor α, have been implicated in both the functional inhibition [ 27] and apoptosis induction [ 28] of islet β cells.
