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Pro-inflammatory cytokines have been implicated in focal cerebral ischemia/reperfusion injury.
22 Mutations in one of the TRP family members, TRPC6, have been implicated in focal segmental glomerulosclerosis (FSGS).
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The RANK/RANKL pathway is critical in osteoclastogenesis and bone destruction, and is implicated in focal bone erosion in rheumatoid arthritis (RA).
This gene has since been implicated in various childhood focal epilepsies [ 60] and ADNFLE [ 61] as well.
2) Several proteins involved in actin filament polymerization (e.g. VASP, INF2, Dia1) have been implicated in regulating actin dynamics in focal adhesions.
The ubiquitin-dependent proteasomal degradation is another proteolytic pathway that has been implicated in the control of focal adhesion turnover and cell migration.
The receptor activator of NF-κB/receptor activator of NF-κB ligand (RANK/RANKL) pathway is critical in osteoclastogenesis and bone erosion and has been implicated in the process of focal bone erosion in rheumatoid arthritis (RA).
Based on the observations that CRN5 interacts with the cofilin-activating phosphatase Slingshot-1 L and knock-down of CRN5 increases the amount of phospho-cofilin, CRN5 has been implicated in the regulation of the focal adhesion turnover rate [ 11].
We note that Reck has additionally been implicated in endocytic trafficking (Miki et al., 2007), focal adhesion formation and cell polarity (Morioka et al., 2009) processes that may affect Wnt/β-catenin signal transduction (Fonar and Frank, 2011; Feng and Gao, 2014).
Focal adhesion pathway has been implicated in the cell migration and initiated metastasis [ 33].
For example, focal adhesion kinase has been implicated in regulating exercise-induced muscle growth (6, 7) and disuse atrophy (8).
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