Sentence examples for been implicated in fibrosis from inspiring English sources
TG2 has been implicated in fibrosis and vascular calcification, both of which lead to a common feature of aging known as arterial stiffness.
In light of fibrosis being the cardinal feature of SSc, it is interesting to note that IL-17 has also been implicated in fibrosis of the basal membrane in asthma [25] and the control of inflammatory response after bleomycin-induce lung injury, a model often exploited to study pulmonary fibrosis [26].
Interleukin (IL -17A and IL -17A(ando known as IL-17E halsobeen implicated in fibrosis in various tissues.
Indeed, TGF-β has been implicated in fibrosis of multiple tissue types including liver, kidney, and airway [ 37- 39].
While the exact cause of myofibroblast persistence remains unclear, the dynamic interplay between these wound-healing cells and the local ECM has been implicated in fibrosis progression.
Interestingly, canonical Wnt signaling has also been implicated in fibrosis, providing a molecular link between fibrosis and angiogenesis (Bowley et al., 2007).
The Hippo pathway is critical for cell growth and cell fate decisions and dysregulation of signaling through this pathway or of its downstream effectors is implicated in fibrosis and cancer [162 165].
The differentially regulated markers of fibrosis are summarized in Table 2. Upregulation of FSP1, Col1a1, and Vim has been implicated in renal fibrosis and the downregulation of the antifibrotic BMP4 and BMP7 confirmed the fibrosis establishment, while central role of TGF- β in human and experimental models for renal fibrosis has been well described [ 3, 4, 17, 18].
TGF-β1 is a major pro-fibrogenic growth factor that has been implicated in lung fibrosis, and cooperation between JNK and TGF-β1 signaling has been observed [30].
Although EMT has been implicated in lung fibrosis, the mechanisms underlying EMT remain unclear.
Dysregulation of the degradation of misfolded and aggregated proteins or the protein quality control pathway has been implicated in Cystic Fibrosis, many neurodegenerative diseases and cancer [28] [31].
