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Proteolytic enzymes have been implicated in facilitating tumor cell invasion and the current study was designed to characterize the expression of the cysteine proteinase cathepsin S (CatS) in astrocytomas and examine its potential role in invasion.
As plasminogen recruitment and the plasminogen-activated fibrinolytic system have been implicated in facilitating microbial pathogenesis, we next examined the influence of capsule formation on the cell wall surface accessibility and plasminogen binding capacity of the serotype D strains JEC21, FCH78 (cap59::nat), and FCH79 (CAP59 cap59::nat) and the serotype A isolates C23 and A1 38-2.
Indeed, neutrophils have been implicated in facilitating tumor cell extravasation.
Importantly, JARID1A has been implicated in facilitating an altered chromatin state that promotes drug-tolerant subpopulations of cancer cells [ 171].
Kallikrein proteins have also been implicated in facilitating angiogenesis via degradation of the cellular matrix [ 109] and our data showed co-regulation of Pgf and Kallikrein genes.
VHL has been implicated in facilitating TNF-α-induced apoptosis by suppressing the expression of NF-κB-dependent anti-apoptotic genes (Qi & Ohh, 2003).
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PELP1 interacts with HER2 and is implicated in facilitating ER crosstalk with HER2 signaling pathways [ 9].
Chemical modifications of the histone amino-terminal tails are implicated in facilitating nucleosome remodeling and repositioning, and in the recruitment of specific transcription factors.
Integrin αvβ3 is implicated in facilitating metastasis of breast cancer cells to bone [ 55]; decreased transcription of ITGAV after MUC1 siRNA may, therefore, suggest that MUC1 is involved in this lethal process as well.
Both CREB and BDNF have been implicated in neuroprotection, as well as in facilitating learning and memory [21], [65], [66], [67], [68], [69].
In particular, these polysaccharides have been implicated in playing a key role in facilitating infection thread initiation and extension in the alfalfa- S. meliloti interactions [ 38, 43, 44].
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