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This protein is highly antigenic and has been implicated in experimental uveoretinitis.
Rictor [ 7] and mTORC2-dependent AKT activation [ 8] have been implicated in experimental lung metastasis.
The signaling pathways Wnt, Hedgehog, TGF-β and Notch have been implicated in experimental and developmental epithelial mesenchymal transition (EMT).
The major metabolite of Dfen, norfenfluramine, is an agonist at the 5-HT2A and 5-HT2B receptors, both of which have been implicated in experimental PAH.
Finally, the alternative pathway has been implicated in experimental renal ischemia/reperfusion injury and might play a dominant role in humans as compared to the MBL pathway [ 33].
DNA methylation is a major epigenetic regulator of gene suppression [ 52], and has been implicated in experimental and human temporal lobe epilepsies [ 36, 53, 79].
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Furthermore, the IGF system has been implicated in both experimental stroke recovery/susceptibility in patients.
As powerful drivers of diapedesis, the chemokines CCL2 and CCL5 have long been implicated in hypertension, but experimental data highlight divergent, context-specific effects of these chemokines on blood pressure and tissue injury.
This significant enhancement in the accuracy confirmed the importance of intramolecular interactions and the inherence of nonadditivity in molecular solvation, which had also been implicated in the precedent experimental and theoretical studies on solute-solvent interactions.
MCs have been implicated in RA and experimental models of this autoimmune disorder.
Direct mucocutaneous contact and respiratory routes have been implicated in epidemiologic and experimental research (15, 18, 19 ).
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