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This is a type of small chromosomal rearrangement that has been implicated in evolution, and has been suggested to be involved in speciation events through population isolation followed by divergent resolution of duplicate genes [ 20, 41].
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For example, altered expression of Msx genes has been implicated in the evolution of direct development in sea urchins [ 20] and caudal fin elaboration of male sword-tailed fishes [ 21].
These results raise the possibility that ASPM and CDK5RAP2 play a consistent role in mammalian brain evolution, as these two loci have previously been implicated in brain evolution in primates [ 8, 21] (the failure to obtain a positive relationship for these two genes in primates here is most likely related to the sample size).
Gene duplication has been implicated in the evolution of transcription factors that play key roles in developmental pathways and are likely involved in morphological evolution [ 3, 4].
The bacterial RecA protein has been implicated in the evolution of antibiotic resistance in pathogens, which is an escalating problem worldwide.
This suggests that an ancestral group II intron may have been implicated in the evolution of the mitochondrial genome and its peculiar rRNA gene organization.
Surprisingly, pdm3 has not been implicated in the evolution of sex-specific pigmentation outside the montium subgroup, suggesting that the genetic paths to sexual dimorphism may be constrained within a clade but variable across clades.
Change in this parameter has also been implicated in the evolution of organismal complexity [55].
Here, aprotinin has been suggested to suppress the transcription of genes which have been implicated in the evolution of the postischemic inflammatory response [13], [14].
Recently, diapause has also been implicated in the evolution of castes in social wasps pointing out that the molecular building blocks of diapause might have been used to regulate reproductive division of labor in some insect societies [10].
Cathepsins play a pivotal role in WCR digestion, and have been implicated in the evolution of rotation resistance.
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