Candidates EDNRA, EDN1 and EDNRB function together in a regulatory pathway with endothelin-converting enzyme ECE1, which has been implicated in essential hypertension.
Interestingly, this gene has been implicated in essential hypertension.
Homologs of the Bemisia metabolism genes of insect origin have also been implicated in essential amino acid synthesis in other sap-feeding insect hosts, indicative of parallel coevolution of shared metabolic pathways across multiple symbioses.
Indeed, AdoMetDC is required for polyamine synthesis, molecules that are implicated in essential plant functions such as cell division, embryogenesis, leaf, root, and flower development, and stress responses [ 21, 22].
SETD8's methyltransferase activity has been implicated in many essential cellular processes including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation.
CMV gB genotype may be an important determinant of viral virulence because gB has been implicated in several essential steps in CMV pathogenesis, such as virus entry, cell fusion, and cell-to-cell spread.
Na+, K+ ATPases have been implicated in numerous essential cellular homeostatic processes, making it surprising that mild hypomorphic loss-of-function mutations affecting this protein would result in increased longevity.
The ATP-binding cassette protein RLI1 (yeast: [SGD YDR091C]) is a conserved factor that has been implicated in several essential cellular processes such as translational initiation [ 32, 33] and translational termination and recycling [ 34].
For instance, CREB has been implicated in multiple functions essential to the brain, including responses to emotional stimuli [ 4], learning and long-term memory formation [ 5- 9].
Autophagy has been implicated in a variety of essential cellular functions, and we have established an important role for autophagy in maintaining mitochondrial function by supporting essential protein synthesis, and mitochondria dysfunction is the major cause of starvation-induced cell death in autophagy-defective mutants.
- Defective autophagy has been implicated in tumorigenesis, as the essential autophagy gene, BECN1, is commonly deleted in breast, ovarian, and prostate cancers.
